Glove boxes are sealed containers designed to allow manipulation of objects where a separate atmosphere is desired. They are commonly used in scientific and industrial applications to handle hazardous substances or materials sensitive to air and moisture. The box is equipped with gloves that are hermetically sealed to ports in the side of the enclosure, allowing users to perform tasks inside the box without direct contact with the contents. Glove boxes can be filled with inert gases like nitrogen or argon to create an oxygen-free environment, which is essential for working with air-sensitive chemicals or materials. They are also used to protect users from hazardous substances, such as radioactive materials or toxic chemicals, by providing a physical barrier. The design of glove boxes can vary, with some featuring additional equipment like vacuum pumps, gas purification systems, or integrated analytical instruments. Limitations include restricted dexterity due to the gloves, potential for leaks if not properly maintained, and size constraints that limit the scale of operations. Despite these limitations, glove boxes are invaluable in fields like chemistry, pharmaceuticals, and materials science, where controlled environments are crucial.